Mixing Covid-19 vaccines tied to more side effects, early UK data suggests

Covid Vaccines and their side effects

People who got mixed doses of coronavirus vaccines -- receiving a different vaccine type as a second dose than the first dose -- appear to be more likely to experience mild side effects such as fever, chills, fatigue or headache, researchers in the UK reported Wednesday.

But the side effects following mix-and-match vaccinations were short-lived and there were no other safety concerns, the researchers reported in the Lancet medical journal.

"These are the type of reactions you do expect with the vaccine," Dr. Matthew Snape, an associate professor of pediatrics and vaccinology at the University of Oxford and chief investigator on the trial, said during a media briefing."They are more or less the same types of reactions that you're seeing with the standard schedules. It's just that they're occurring more frequently, and we're seeing both more frequent both in mild and moderate symptoms -- but they resolved quickly," Snape said.

Overall, "it's a really intriguing finding," he said, "and it's not something necessarily we were expecting -- to see such a consistent signal."
It's something to keep an eye out for when giving mixed doses, the researchers said.
"One of the things it's telling us is that, for example, you wouldn't want to immunize a ward full of nurses on the same day with a mixed schedule," Snape said. "Because you may have higher rates of absenteeism in the next day."


The mix-and-match trial
The new research included 830 volunteers 50 and older who were randomly assigned to four different vaccine schedules involving the Oxford/AstraZeneca and Pfizer/BioNTech vaccines, with first and second doses given 28 days apart.
They either got the AstraZeneca vaccine as both doses; AstraZeneca as a first dose and Pfizer as a second dose; the Pfizer vaccine as both doses; or the Pfizer vaccine as a first dose and AstraZeneca as a second dose.

The researchers found that people who got different vaccines had more side effects following the second dose, with feverishness reported by 34% of those who received the AstraZeneca vaccine first and Pfizer vaccine second, compared with 10% of those given the AstraZeneca vaccine for both doses.
Fever was reported by 41% of the people who received the Pfizer vaccine first and AstraZeneca vaccine second, compared with 21% of the volunteers given the Pfizer vaccine for both doses.


"Similar increases were observed for chills, fatigue, headache, joint pain, malaise, and muscle ache," the researchers wrote. They noted that people could take acetaminophen -- sold under brand names such as Tylenol -- to ease the side effects.
There were no hospitalizations due to the symptoms and most of the increased reactions were seen within 48 hours after immunization, the researchers found. They noted that they did not see evidence of a rare blood clotting syndrome that's been linked with the AstraZeneca and Johnson & Johnson vaccines in any of the volunteers within a week after the second dose.


The researchers also noted that their findings are based on initial data and there are now ongoing studies testing mixed administration of vaccines made by Moderna and Novavax.
More research is also needed to evaluate immune responses following different types of schedules, and whether increased side effects suggest that schedules using different types of vaccines elicit strong immune responses.
"We do think reactions often relate to the stimulating of the innate immune response," Snape said. "Whether or not this will relate to actually an improved immune response we don't know yet. We'll be finding out those results in a few weeks time."

https://edition.cnn.com/2021/05/12/health/covid-19-vaccines-mixing-study-lancet/index.html

Tags : #CovidVaccine #CovidVaccineSideEffects #JJVaccines #PfizerVaccine #ModernaVaccine

About the Author


Team Medicircle

Related Stories

Loading Please wait...

-Advertisements-




Trending Now

Sexual wellness superstore, Love Depot launches digital campaign to deliver every desireMarch 28, 2024
Recharge Your Life: Simple Ways to Boost Your Physical and Mental EnergyMarch 28, 2024
The Neurological Toll of Common Household Chemicals: Insights from Recent ResearchMarch 28, 2024
The Aging Puzzle: Decoding the Mechanisms of AgingMarch 28, 2024
The Double-Edged Sword of Kala-azar Treatment: Shedding Light on Eye ComplicationsMarch 28, 2024
FTCCI Launches Industry-Academia Connect to improve the employability of Engineering Graduates and address the growing demand for Talent in Emerging TechMarch 27, 2024
NTT and Olympus Begin World's First Joint Demonstration Experiment of Cloud Endoscopy SystemMarch 27, 2024
NTT and Olympus Begin World's First Joint Demonstration Experiment of Cloud Endoscopy SystemMarch 27, 2024
2nd Edition of IIFL JITO Ahimsa Run for peace & for non-violence to be held on 31st MarchMarch 27, 2024
Brij Hotels Announced 4 Million in Series A Funding March 27, 2024
Combatting Childhood Sedentariness: The Key to Preventing Premature Vascular DamageMarch 27, 2024
Crucial Findings: Unlocking Paths to Combat Ebola's DevastationMarch 27, 2024
Guarding Against Disease: The Crucial Role of Oral Hygiene in Preventive HealthcareMarch 27, 2024
Sanofi & Cipla announce exclusive distribution partnership to expand reach of CNS portfolio in IndiaMarch 26, 2024
Surmandal's Tribute to the Legends of Hindustani Classical MusicMarch 26, 2024
In Moscow, over 350,000 mammograms have been analyzed using artificial intelligence as part of the compulsory health insurance programMarch 26, 2024
Embark on a Creative Journey: "Kala For A Cause" Unveils Pottery Workshop Series March 26, 2024
Healthtech pioneer Aurora Innovation appoints new CEO – expands in Europe with service that streamlines patient-healthcare interactionMarch 26, 2024
In A Rare Feat, 45 YO Woman Walks Within 6 Hrs. Of Dual Robotic Surgery In A Single Operation At HCGMCCMarch 26, 2024
Improve Cancer Care through Automated CT Analysis: Oncoshield – CTMarch 26, 2024