Depression and anxiety in mums-to-be linked to heightened asthma risk in their kids

▴ Depression and anxiety in mums-to-be linked to heightened asthma risk in their kids
Risk of later life respiratory disease likely programmed in womb, say researchers

Depression and anxiety in mums-to-be are linked to a heightened risk of asthma and poorer lung function in their 10-year-old children finds research published online in the journal Thorax.

The findings suggest that the risk of later life respiratory disease is likely programmed in the womb, rather than necessarily influenced by as yet unmeasured genetic, social or environmental factors, say the researchers.

Psychological distress, to include anxiety and depression, during pregnancy is associated with increased risks of respiratory disease in preschoolers, but whether this association persists into later childhood isn’t known.

To find out, the researchers drew on participants in the Generation R Study, a population-based prospective cohort study, which has been tracking life from early pregnancy onwards in Rotterdam, the Netherlands.

The degree of overall psychological distress, depression and anxiety experienced by each parent in the second term of pregnancy and 3 years after the birth, was assessed, using a validated 53-item questionnaire (Brief Symptom Inventory).

Depression and anxiety were assessed only in the mothers, at 2 and 6 months after birth.

In all, 362 (nearly 9%) of the mothers and 167 (just under 4%) of the fathers were clinically depressed and/or anxious during the pregnancy.

The lung function of 3757 of the offspring was measured when they were 10 years old, and information on asthma obtained in 3640 of them. Almost 6% (213) had asthma.

Mothers’ overall psychological distress and symptoms of anxiety and depression during pregnancy were all associated with a 45-92% increased risk of current asthma in their children, after adjusting for potentially influential factors, such as age, ethnicity, smoking during pregnancy, and pet keeping.

Factoring in fathers’ psychological distress during pregnancy didn’t change this association.

And only mothers’ overall psychological distress during pregnancy was associated with one of three measures of lung power, the FVC, which was lower in their children. The children of mothers with depressive symptoms also had a lower FEV1, another measure of lung function.

Further analysis of the patterns of psychological distress showed that mostly depressive or anxiety symptoms both during and after pregnancy were associated with a heightened risk of asthma in the children.

But separating out the potentially influential factors into three different groups, including lifestyle and health-related, socioeconomic, and birth and early childhood factors, made no difference to the associations found.

Nor did fathers’ psychological distress during pregnancy: this wasn’t associated with poorer lung function or asthma in their children.

This is an observational study, and as such, can’t establish the cause. And a few other studies have looked at the potential impact of a mother’s distress during pregnancy on the health of her child(ren).

Nevertheless, there are plausible biological explanations for the findings, suggest the researchers. These include excess production of various hormones prompted by psychological distress: glucocorticoids, for example, are key to fetal lung development.

They conclude: “Our results may indicate an intrauterine effect of maternal psychological distress during pregnancy on fetal lung development and respiratory morbidity, rather than an effect of unmeasured genetic, social, behavioural or environmental factors.”

Tags : #PrecautionsforPregnantWomen #LatestResearchonDepression13thOct #AsthmainChildren #JournalThorax #TheBMJ

About the Author


Team Medicircle

Related Stories

Loading Please wait...

-Advertisements-




Trending Now

Surviving Against the Odds: Steven Spinale's Journey After an Ingrown Hair Turns DeadlyMarch 29, 2024
10 reasons why media research and Planning are essential in Healthcare marketingMarch 29, 2024
The Surprising Link Between Sleep and Age Perception: What You Need to KnowMarch 29, 2024
The Dark Side of Beauty: Kidney Damage from Hair Straightening TreatmentsMarch 29, 2024
The Dark Side of Beauty: Kidney Damage from Hair Straightening TreatmentsMarch 29, 2024
Avance Clinical at World Vaccine Congress to Share Latest Vaccine Clinical Trial News Including an HIV-1 StudyMarch 29, 2024
Sexual wellness superstore, Love Depot launches digital campaign to deliver every desireMarch 28, 2024
Recharge Your Life: Simple Ways to Boost Your Physical and Mental EnergyMarch 28, 2024
The Neurological Toll of Common Household Chemicals: Insights from Recent ResearchMarch 28, 2024
The Aging Puzzle: Decoding the Mechanisms of AgingMarch 28, 2024
The Double-Edged Sword of Kala-azar Treatment: Shedding Light on Eye ComplicationsMarch 28, 2024
FTCCI Launches Industry-Academia Connect to improve the employability of Engineering Graduates and address the growing demand for Talent in Emerging TechMarch 27, 2024
NTT and Olympus Begin World's First Joint Demonstration Experiment of Cloud Endoscopy SystemMarch 27, 2024
NTT and Olympus Begin World's First Joint Demonstration Experiment of Cloud Endoscopy SystemMarch 27, 2024
2nd Edition of IIFL JITO Ahimsa Run for peace & for non-violence to be held on 31st MarchMarch 27, 2024
Brij Hotels Announced 4 Million in Series A Funding March 27, 2024
Combatting Childhood Sedentariness: The Key to Preventing Premature Vascular DamageMarch 27, 2024
Crucial Findings: Unlocking Paths to Combat Ebola's DevastationMarch 27, 2024
Guarding Against Disease: The Crucial Role of Oral Hygiene in Preventive HealthcareMarch 27, 2024
Sanofi & Cipla announce exclusive distribution partnership to expand reach of CNS portfolio in IndiaMarch 26, 2024